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KMID : 0861020120270010027
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Korea Journal of Herbology
2012 Volume.27 No. 1 p.27 ~ p.34
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Preventive effects of Saponariae Vaccariae Semen and Melandryi Firmi Herba on hyperlipidemia and liver damage induced by alcohol
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Choi Jae-Young
Seo Bu-Il
Oh Dal-Seok
Park Ji-Ha
Roh Seong-Soo
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Abstract
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Objectives: This study was performed to compare the preventive effect of water extracts from Saponariae
Vaccariae Semen(SVS) and Melandryi Firmi Herba(MFH) on hyperlipidemia and liver damage induced by alcohol.
Methods: Except for the normal group, I fed rat on 25% alcohol for 55 days. And each extract was
administrated for the same period. I measured the serum component in rat’s blood, body weight and weight of
liver.
Results: At first, I observed effects of SVS and MFH on hyperlipidemia induced by alcohol. SVS and MFH
group didn’t show the significant decrease of total cholesterol in comparison with those of the control group.
SVS and MFH group showed the significant increase of HDL-cholesterol in comparison with those of the
control group. SVS group showed the significant decrease of triglyceride in comparison with those of the
control group, but MFH group didn’t show the significant decrease of triglyceride in comparison with those of
the control group. SVS group showed the significant increase of body weight in comparison with those of the
control group at 4weeks and 8weeks. But, MFH group didn’t show the significant changes of body weight in
comparison with those of the control group at 4weeks and 8weeks. By the way, SVS group showed the
significant decrease of triglyceride in comparison with those of MFH group. SVS group showed the significant
increase of body weight in comparison with those of MFH group at 8weeks. At second, I observed effects of
SVS and MFH on liver damage induced by alcohol. SVS and MFH group showed the significant decrease of
AST(aspartate aminotransferase), ALT(alanine aminotransferase), ALP(alkaline phosphatase) and LDH(lactate
dehydrogenase) in comparison with those of the control group. SVS group showed the significant increase of
liver weight in comparison with those of the control group, but MFH group didn’t show the significant increase
of liver weight in comparison with those of the control group. By the way, SVS group showed the significant
increase of liver weight in comparison with those of MFH group.
Conclusions: Reviewing these experimental results, it suggests that water extracts from SVS and MFH have
pharmaceutical preventive efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further
additional study should be conducted to elucidate the pharmaceutical efficacy of these in depth.
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KEYWORD
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Saponariae Vaccariae Semen, Melandryi Firmi Herba, hyperlipidemia, liver damage, alcohol
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